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The UC-II® difference

NOT ALL COLLAGENS ARE CREATED EQUAL!

UC-II®, a patented form of Undenatured Type-II Collagen, is effective through a unique process called oral tolerance, which down-regulates the immune system’s response that causes inflammation. 

Oral Tolerance reduces inflammation and facilitates cartilage repair, reducing dogs’ joint pain and improving mobility.

UC-II® has been clinically proven in multiple studies to significantly improve joint health and mobility in both healthy and arthritic dogs.  

Dogs can experience faster and more effective relief from joint pain, stiffness, and inflammation with UC-II® compared to traditional type II collagen supplements, as the patented low-temperature process preserves the 3D structure of the collagen, which enhances it’s bioavailability and absorption.

UC-II® comes from chicken sternum cartilage and has many studies to show its benefits in both healthy and arthritic dogs to support joint comfort, flexibility and mobility

What are the benefits of UC-II® in dogs ?

UC-II® aids in significantly reducing pain and inflammation, and as a result, it supports joints and connective tissue to improve flexibility and mobility for adult and senior dogs.

By providing targeted support for the immune system and addressing the underlying causes of joint inflammation, UC-II® collagen can help dogs of all ages maintain healthy joint function and mobility.

In addition, it helps support your dogs’ ability to run, walk and jump, giving you visible results in just a few weeks.

UC-II® is a safe and effective way to decrease pain associated with joint inflammation while helping repair and rebuild damaged joints in dogs.

Is UC-II® scientifically proven in dogs?

Numerous research studies in humans and dogs and horses have been conducted and published in peer-reviewed journals. 

Following 120 days of treatment in dogs on UC-II®

After 30 days:

33% reduction in overall pain

After 60 days:

66% reduction in pain upon limb manipulation

44% reduction in exercise-associated lameness

After 120 days:

62% reduction in overall pain

91% reduction in pain upon limb manipulation

78% reduction in exercise-associated lameness

The dogs were more playful and energetic!

None of the dogs showed any signs of adverse effects.
There were no significant changes in any markers of liver function (ALT or bilirubin) or renal or heart function (BUN and creatinine)

What makes UCI® collagen unique to other collagens used in pet supplements?

  • UC-II® is 100% human grade, is well established in human and pet medicine 
  • This undenatured type II collagen is so effective because it undergoes minimal processing when extracted in a patented process.
  • In addition, undenatured type II collagen keeps the same 3D structure as it does in animals & humans. Therefore the body can recognize it, absorb it quickly & adequately react to it to stop the inflammation for maximum benefit.
  • On the contrary, type II collagen treated by heat or hydrolysed ( as found in most other supplements) will lose its specific 3D structure; it is called denatured type II collagen and no longer resembles that in the body of your dog. 
  • They can take a long time to absorb or may not be effective at all, whereas UCI® begins working within minutes after consumption making it ideal for treating chronic joint issues.

How does UC-II® work on pain and inflammation in dogs?

UC-II® reacts with the body’s immune system to improve crippling signs and symptoms of arthritis.  Type II collagen is the main structural protein found in cartilage & connective tissue, providing strength, toughness, flexibility and support to joints.

UC-II® functions through a process called oral tolerization.  This process takes place in the small intestine where food is absorbed.  Through a complex series of immunological events, patches of lymphoid tissue (Peyer’s Patches) surrounding the small intestine, screens incoming compounds and serves as a “switch” to turn the body’s immune response to foreign substances on or off. 

This interaction between UC-II and the cells deactivates the immune reactions that cause inflammation and painthis is the phenomenon of oral tolerance.

So not only does UC-II® provide cartilage components to the body, its natural, undenatured 3D structure prevents the immune system from attacking the articular cartilage of your dog’s body.

When using supplements containing UC-II®, you will notice an improvement in your dog’s mobility, as the pain decreases after a few weeks. As you continue to give UC-II® to your dog, you will see them feeling better and more active.

References

  1. D’Altilio M, Peal A, Alvey M, et al. Therapeutic Efficacy and Safety of Undenatured type II collagen singly or in combination with glucosamine and chondroitin in arthritic dogs. Toxicol Mech Methods. 2007;17(4):189-96.
  2. Deparle LA, Gupta RC, Canerdy TD, et al. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II®) in therapy of arthritic dogs. J Vet Pharmacol Ther. 2005 Aug;28(4):385-90.
  3. Bagchi D, Misner B, Bagchi M, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.
  4. Gupta RC, Canerdy TD, Lindley J, et al. Comparative therapeutic efficacy and safety of type-II collagen (UC-II®), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate. J Anim Physiol Anim Nutr (Berl). 2012 Oct;96(5):770-777
  5. Gupta RC, Canerdy TD, Skaggs P, et al. Therapeutic efficacy of undenatured type-II collagen (UC-II®) in comparison to glucosamine and chondroitin in arthritic horses. J Vet Pharmacol Ther. 2009 Dec;32(6):577-84.
  6. Peron JP, de Oliveira AP, Rizzo LV. It takes guts for tolerance: the phenomenon of oral tolerance and the regulation of autoimmune response. Autoimmun Rev. 2009 Sep;9(1):1-4.